Calibre的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到附近那裡買和營業時間的推薦產品

Robert L Thompson: TVA Architects

為了解決Calibre的問題，作者Robert L. Thompson, Faia 這樣論述：

- Showcases the design innovations of the highly regarded and influential Portland-based architect, Robert L Thompson- Features richly illustrated photography and detailed illustrations- Includes many high-calibre works, including many retail design complexes for Nike, air hangars, commercial and

public works, and residential condominiums, towers, and single-family homesRobert L. Thompson, FAIA, is the founder and lead design principal of the Portland-based firm TVA Architects, a firm that has built a foundation of collaboration, innovation, and conservation through beautiful design. He is

responsible for the design of many of the most prominent buildings throughout Oregon and the Pacific Northwest. TVA Architects creatively transforms their clients’ needs and aspirations into elegantly understated works of meaningful architecture, meticulously detailed and impeccably crafted.The proj

ects documented in this book coincide with the fortieth anniversary of this celebrated architect and his body of work as a designer and innovator.He founded TVA Architects in 1984 and built an internationally recognized practice, starting in the Pacific Northwest. In 1993, at the age of thirty-nine,

Thompson was the youngest architect in America to be inducted into the American Institute of Architects’ College of Fellows for his contribution to the profession. Thompson and TVA Architects have been honored with scores of local, national, and international awards for excellence in design.His pro

jects have ranged from major corporate campuses, high-rise office towers and condominium towers, sports and recreational facilities, retail and cultural projects as well as multi- and single-family residences. This lavishly illustrated monograph, filled with full-color photography and detailed plans

, forms a compilation of select work that celebrates Thompson’s influence across architecture over several decades.

Calibre進入發燒排行的影片

應用程式偵測積體電路佈局設計中的漏電

為了解決Calibre的問題，作者楊雅媛 這樣論述：

摘要本論文將針對因互補式金屬氧化物半導體(CMOS, Complementary Metal-Oxide-Semiconductor)高壓製程實際電路設計不當並無法靠模擬程式和驗證程式找出錯誤而造成漏電的問題做分析和提供解決方法。在CMOS非高壓製程設計時P型金氧半場效電晶體(PMOS, P-Metal-Oxide-Semiconductor)與N型金氧半場效電晶體(NMOS, N-Metal-Oxide-Semiconductor)皆是四端點的元件分別是源極(Source)、閘極(Gate)、汲極(Drain)、基極(Bulk)，但高壓製程步驟需要PMOS加上N型深井(Deep-NWell

)，因此PMOS會變為五端點的元件，而NMOS會因為加上Deep-NWell 則變為六端點的元件。 但在電路設計時PMOS與NMOS均只有四個端點，所以沒有PMOS的第五端點與NMOS的第五和第六端點的定義，因此，當進行IC實體電路設計時因Deep-NWell不允許浮接，所以這第五端點的電位要接到什麼電位就是最大的風險。 而在電路設計模擬時只能模擬出來四個端點的結果，因此不會察覺到任何錯誤，本論文將此部分定義為「實體電路盲區」。「實體電路盲區」會導致漏電，這個現象的形成是由半導體的P型與N型介面形成PN介面的二極體(Diode)導通的過程所造成的漏電現象，這會造成耗電量急遽增加，大幅超越原本的

規劃。 本論文利用電路設計階段所有的應用，思考整體架構後，使用IC實體電路設計的驗證軟體Calibre撰寫驗證程式，將這個寄生二極體導通的部分加以除錯(Debug)以避免漏電(Leakage)。

Shadows Reel

為了解決Calibre的問題，作者Box, C. J. 這樣論述：

C. J. Box is the author of twenty Joe Pickett novels, six stand-alone novels, and a story collection. He has won the Edgar, Anthony, Macavity, Gumshoe, and Barry Awards, as well as the French Prix Calibre .38, and has been a Los Angeles Times Book Prize finalist. A Wyoming native, Box has also worke

d on a ranch and as a small-town newspaper reporter and editor. He lives outside Cheyenne with his family. His books have been translated into twenty-seven languages. He’s an executive producer of ABC TV’s Big Sky, which is based on his Cody Hoyt/Cassie Dewell novels, as well as executive producer o

f the upcoming Joe Pickett television series for Paramount Studios/Spectrum Originals.

中藥複方製劑芍藥甘草湯和Coumarin-chalcone衍生物在Tau蛋白易聚集表現之阿茲海默氏症細胞模式中之療效

為了解決Calibre的問題，作者林德嫻 這樣論述：

阿茲海默氏症(Alzheimer’s disease, AD)為一種進行性且不可逆的神經退化性疾病，受損的記憶和認知能力會逐漸失常最終造成身體功能的完全喪失。AD病人腦中最主要的特徵為不正常的Amyoild β與Tau蛋白聚集形成的老化斑塊(Senile plaque)和神經纖維纏結(Neurofibrillary tangles)。神經纖維纏結主要組成是高度磷酸化的Tau蛋白，而Tau蛋白的病變不僅在AD病人，也在許多Tauopathy中見到。在大腦中由於錯誤折疊形成的蛋白堆積，引發許多病理事件，例如氧化壓力、神經發炎，或是與神經細胞功能相關的訊息傳遞障礙，降低神經細胞存活。本篇研究主要是

利用人類胚胎腎細胞HEK-293和神經纖維瘤母細胞SH-SY5Y，表現易聚集特性的ΔK280 TauRD片段蛋白，作為評估中藥製劑芍藥甘草湯(SG-Tang)以及Coumarin-chalcone衍生物LM-021、LM-031和LMDS-1~4化合物，抑制蛋白聚集、抗氧化和神經保護性的情形。芍藥甘草湯製劑，由甘草與白芍以等比例製成，除了可有效降低以LPS/IFN-γ刺激後活化的BV-2微膠細胞所釋出的NO、TNF-α、IL-1β及IL-6等前驅發炎細胞因子外，並可抑制由於誘導表現ΔK280 TauRD蛋白而上升的BAD、BID、CASP3、CASP8和CYCS表現，來達到Tau蛋白聚集抑制和

神經保護性。其中LM-021除了本身有化學伴護活性可直接抑制ΔK280 TauRD的聚集外，還可透過PKA、CaMKII、ERK等路徑活化CREB和下游的BDNF、BCL2表現，來展現其神經保護之功能。接著在ΔK280 TauRD-DsRed SH-SY5Y細胞中，觀察到LM-031可提升HSPB1伴護蛋白表現以降低Tau蛋白的錯誤折疊，以及藉由活化NRF2/NQO1/GCLC和CREB調控之BDNF/AKT/ERK/BCL2路徑，來達到抑制細胞凋亡和促進細胞存活之效果。最後，因LM-031可提升CREB依存的BDNF表現，利用虛擬篩選找出LM-031類似化合物LMDS-1~4，並進一步以TR

KB與ligand作用的d5-domain (PDB 1hcf)，以分子模擬計算LM-031類似化合物與此蛋白片段的結合構形。細胞實驗結果顯示，LMDS-1和LMDS-2可經由TRKB/ERK和TRKB/PI3K/AKT訊息路徑，增加CREB磷酸化及其下游BDNF、BCL2基因表現。總結來說，本研究結果顯示芍藥甘草湯的抗氧化和抗發炎活性，可抑制神經細胞凋亡，在Tau蛋白聚集的細胞中展現其神經保護的能力，而Coumarin-chalcone衍生物LM-031、LM-021、LMDS-1、LMDS-2，具有活化HSPB1、NRF2及/或TRKB的作用，來降低Tau蛋白的錯誤摺疊、抑制細胞凋亡和促進

神經細胞存活。以上這些研究結果顯示了芍藥甘草湯和Coumarin-chalcone衍生物，應用在AD治療上的潛能。