Epic的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到附近那裡買和營業時間的推薦產品

The World Atlas of Art Nouveau Architecture

為了解決Epic的問題，作者Bercedo, Ivan/ Mestre, Jorge (EDT) 這樣論述：

The result of years of research, this epic volume shows the global reach of the Art Nouveau idiomModernismo, Jugendstil or Art Nouveau--the different names given to Art Nouveau in different geographical contexts highlight the territorial scope and diversity of the style, but also its common featu

res: it was new, modern, young and groundbreaking. Whether in Austria, Spain, Denmark or Russia, Art Nouveau defined itself as something that opposed tradition and broke with the past.Rejecting a classicizing academic grammar, and reaching deep into the fantastical for inspiration (from the imagined

history of the medieval to the Orientalist exotic), artists and architects such as Victor Horta, Hector Guimard, Viollet-le-Duc, William Morris, Otto Wagner, Samuel Bing and the Goncourt brothers created a new style with a holistic vision, embracing architecture, painting, graphic art, interior des

ign, textiles, ceramics and metalwork. Imaginative form was matched by innovative building techniques. The architects of Art Nouveau were some of the first to experiment with building with iron, glass, pottery and prefabricated concrete; their buildings offer instructive models of industrial develop

ment and collaborative design. Beautifully illustrated and exhaustively researched, The World Atlas of Art Nouveau Architecture brings together a selection of key Art Nouveau buildings in a truly global survey that includes, for the first time, examples of the style outside of Europe. Exemplars of t

he form were chosen through a rigorous selection process involving a panel of expert advisors with specialist input from each world region. A general introduction to the style grounds the selection, and short essays explain how Art Nouveau differed in different cities and countries. The World Atlas

of Art Nouveau Architecture honors one of the world's first truly global modern art movements.

Epic進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Epic的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Honey, Baby, Mine

為了解決Epic的問題，作者Dern, Laura,Ladd, Diane 這樣論述：

A collection of deeply personal conversations from award-winning actress and activist Laura Dern and the woman she admires most, her mother--legendary actress Diane Ladd--that take readers on an intimate tour of their lives, sharing their most honest conversations on love, life, success, and ever

ything in between. Award-winning actresses and mother-daughter duo Laura Dern and Diane Ladd are the kind of women who draw strength from their lifelong friendships with other women, and most of all, from each other. Ever since Laura was born, the two have leaned on one another through the trials of

everyday life and the tribulations that come with even the most storied Hollywood careers. They were always close, but when Diane developed a sudden illness, their relationship grew even deeper. When a doctor prescribed long walks to build back Diane’s lung capacity, the pair began taking strolls

together every day. These meandering walks soon became epic ones, and the conversations the two women shared began to break down the traditional barriers between mothers and daughters. With topics ranging from ambition and legacy to intimacy and marriage, ranging from humorous to deeply poignant, no

thing was off limits. By the time Diane was healed they were more than a close pair; they had covered tremendous ground and formed a true friendship. Peppered throughout these intimate exchanges, they enclose personal photos, family recipes, and much more. The result is a book that will make you wan

t to call your own mom--a testament to the intimacy that can be achieved when we are brave enough to speak our truths to those we love most.

賦名正當性：以Facebook為例

為了解決Epic的問題，作者阮氏嘉如 這樣論述：

合法性被認為是戰略管理理論中的一個重要結構。然而，對於所有組織來說，獲得合法性總是很容易的，尤其是基於新技術運營和開發的新企業。我們的研究對像是數字平台 Facebook 的創始人兼 CEO 馬克·扎克伯格。本研究借鑒歸因理論，旨在探討運營數字平台的企業家如何為其組織構建框架策略。我們使用基於定性的行動研究程序，討論馬克·扎克伯格如何利用一系列戰略行動為 Facebook 構建合法性框架策略。這些戰略行動包括符號管理、印像管理和信任管理。馬克扎克伯格使用符號管理來創建 Facebook 的標識； 印像管理以建立積極的品牌形象； 信任管理，以獲得組織的公信力。這項研究表明，框架是塑造尋求組織合

法性戰略的一個因素。我們最後討論了我們的研究對理論和戰略實踐的影響。然而，這項研究存在一定的局限性，需要進一步探索。關鍵詞：合法性、數字平台、框架、符號管理、印像管理、信任管理