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Hamas and the Arab Uprisings: Resistance, Allegiance and the Departure from Syria

為了解決GLOBAL WORK的問題，作者Musgrave, Nina 這樣論述：

Nina Musgrave is Assistant Director & Teaching Fellow at the Centre for Defence Studies at King’s College, London, U.K. She has published in the book Terrorism and Political Violence and in the journal Global Discourse. She also conducts defence consultancy work for governments in the Middle East.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決GLOBAL WORK的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Accidental Business Nomad: A Survival Guide for Working Across a Shrinking Planet

為了解決GLOBAL WORK的問題，作者Hegarty, Kyle 這樣論述：

Kyle D. Hegarty, originally from Boston, lives and works in Singapore where he is the Managing Director of TSL Marketing, a global consulting firm that helps businesses grow their sales and marketing capabilities across new markets. At TSL, Kyle runs the Cross-Cultural Leadership Division where he h

elps clients such as: Salesforce, Google, Lufthansa, INSEAD, Thomson Reuters, and Microsoft wrestle with global growth challenges. He is a frequent speaker and trainer around the world. MSNBC, CNN, The Straits Times, Singapore Business Review, Fortune Magazine, and other online publications have fea

tured his work.

共享經濟中餐飲外送平台之實務研究

為了解決GLOBAL WORK的問題，作者李慧芝 這樣論述：

於2020年1月23日中國大陸湖北省武漢市因爆發了新冠疫情，大陸政府把1100萬人口的武漢市封城，整個城市如同被按下暫停鍵，接下來病毒漫延全世界。從這時起，許多人都不出門用餐了，改為在網路上訂餐外送，全球的外送平台行動科技創新公司，在這次的封城，發揮了最大的幫助，線上外賣平台大成長，研究者也是在疫情期間開始使用外賣訂餐平台的服務。外賣平台是共享經濟中再細分出來餐飲外送服務，是從行動科技的創新商業模式的新經濟，用手機的行動科技促成了餐飲商家、客戶、外送員三方面的社會工作協同媒合創新經濟，這是研究目的。而研究者也從訂餐的消費者體驗，加入外賣送餐的服務，參與了行動科技所帶動的共享經濟的創新，以及發

送問卷做分析，這是論文的研究方法。再將研究目的及研究範圍的分析，做出研究結論寫出本論文。