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The World Awaits

為了解決TIME 100 2021的問題，作者Roberts (Tomfoolery), Tomos 這樣論述：

The second inspiring picture book from the creators of The Great Realisation.’All the things that make life wonderful, all the colours, sounds and tastesBegin to lose a touch of magic when your goodness goes to waste.’We all have within us ’potential’, an amount of positivity and goodness that we co

uld add to the world if we only try.But what if we don’t try? What if it all seems too much and we just feel like staying in bed?As one little boy lies in bed one morning, not wanting to face the day, it’s up to his older brother to show him the extraordinary potential within him and how even the sm

allest of his actions will make the world a better place . . .Tomos Roberts’ sparkling new picture book is a manifesto for our time - urging us all to come together to build a brighter future, one small step at a time.Tomos Roberts’ pandemic poem, The Great Realisation, was viewed over 60 million ti

mes online and translated into over 20 languages. It was adapted by Ashley Banjo and Diversity into a BAFTA-winning dance performance for Britain’s Got Talent as well as being featured in the official BBC New Years Eve 2021 fireworks spectacular. The picture book adaptation has been nominated for th

e Kate Greenaway Medal.’A beautiful book and beautifully illustrated’ - Kate Garraway, Good Morning Britain on The Great RealisationTomos was commissioned by the Royal British Legion to write an Armistice Day poem, Alive With Poppies, which he performed at the Royal Albert Hall in commemoration of 1

00 years of the poppy. He wrote a Christmas poem, ’I Actually, Love London’ for BBC London in December 2021. Tomos Roberts (Tomfoolery) is a spoken-word poet and filmmaker, born in New Zealand and brought up in London. His online poem The Great Realisation, launched in April 2020 and has been view

ed over 60 million times. Tomos has been interviewed on This Morning, by Phillip Schofield and Holly Willoughby, and his story has been reported all over the world. His second picture book, The World Awaits published in July 2021, and he was commissioned by the Royal British Legion to write an Armis

tice Day poem, Alive With Poppies, which he performed at the Royal Albert Hall. Tomos lives in London.Nomoco is the illustrator of the Greenaway Medal-nominated Once Upon a Raindrop, also shortlisted for the UKLA Award Information Books category. She has produced artwork for clients including Moschi

no, Marc Jacobs, the Guardian and the New York Times, as well as being exhibited all over the globe. She lives in Tokyo.

TIME 100 2021進入發燒排行的影片

父母親身體狀況與嬰幼兒先天性缺陷之關聯性研究

為了解決TIME 100 2021的問題，作者陳悠祈 這樣論述：

隨著社會經濟壓力逐漸增大，晚婚生子成了趨勢。根據內政部人口統計，西元2019年台灣女性生育第一胎年齡在35歲以上者高達23％，約為西元2009年的2.4倍。高齡產婦的增加，導致妊娠糖尿病、羊水過多、懷孕引起之高血壓等妊娠風險上升，進而造成出生兒的先天性缺陷風險增加。近來，商業保險中的婦嬰險推展，不僅提供產婦保障，同時為新生兒帶來保障。且因應客戶需求，不再侷限於孩子一兩年短期的保障，也觀察其多年後的情形，加強對特定先天缺陷及相關住院、手術醫療面的給付。此外，一般保險公司在提供此保障時，產婦需要填寫健康告知聲明書，藉此預測未來承保的風險，然而父親對嬰幼兒先天缺陷隱含的潛在危險因子可能仍需

再列入考量。因此本研究期望透過「衛生福利部衛生福利資料科學中心」所提供之資料，藉由廣義線性模型，探討2004年至2017年0-7歲嬰幼兒之先天缺陷與父母親危險因子的關聯性。 研究顯示，觀察西元2004年至2017年的2,326,774位新生兒，其0-7歲罹患先天缺陷的機率為4.067%，當中約有20%的先天缺陷者於2歲後才發覺。在其他條件皆相同之下，父親年齡、母親年齡增加十歲時，則會分別使嬰幼兒其先天缺陷率提高為原本的1.013倍（95%CI=0.995-1.031）、1.185倍（95%CI=1.162-1.209）。而母親有任一懷孕危險因子所生育的嬰幼兒其先天缺陷率(例如:心臟疾病、

孕期抽煙、妊娠糖尿病)則是母親無任一懷孕危險因子的1.144倍（95%CI=0.995-1.314）-2.003倍（95%CI=1.932-2.077）之間。希望藉由本研究所得先天缺陷相關資訊，提供保險公司作為訂價上風險的評估，也使雙親藉由事先瞭解懷孕的危險因子能有效做好相關的預防措施，在生育的路上更加順利。

Untitled 8540

為了解決TIME 100 2021的問題，作者Random House Group 這樣論述：

A deeply moving and brilliantly idiosyncratic visual book of days by the National Book Award-winning author of Just Kids and M Train, featuring more than 365 images and reflections that chart Smith’s singular aesthetic--inspired by her wildly popular Instagram.In 2018, without any plan or agenda fo

r what might happen next, Patti Smith posted her first Instagram photo: her hand with the simple message ＂Hello Everybody!＂ Known for shooting with her beloved Land Camera 250, Smith started posting images from her phone including portraits of her kids, her radiator, her boots, and her Abyssinian ca

t, Cairo. Followers felt an immediate affinity with these miniature windows into Smith’s world, photographs of her daily coffee, the books she’s reading, the graves of beloved heroes--William Blake, Dylan Thomas, Sylvia Plath, Simone Weil, Albert Camus. Over time, a coherent story of a life devoted

to art took shape, and more than a million followers responded to Smith’s unique aesthetic in images that chart her passions, devotions, obsessions, and whims. Original to this book are vintage photographs: anniversary pearls, a mother’s keychain, and a husband’s Mosrite guitar. Here, too, are photo

s from Smith’s archives of life on and off the road, train stations, obscure cafés, a notebook always nearby. In wide-ranging yet intimate daily notations, Smith shares dispatches from her travels around the world. With over 365 photographs taking you through a single year, A Book of Days is a new w

ay to experience the expansive mind of the visionary poet, writer, and performer. Hopeful, elegiac, playful--and complete with an introduction by Smith that explores her documentary process--A Book of Days is a timeless offering for deeply uncertain times, an inspirational map of an artist’s life.

Patti Smith is the author of the National Book Award winner Just Kids, as well as M Train, Year of the Monkey, and numerous collections of poetry and essays. Her seminal album Horses has been hailed as one of the top 100 albums of all time. In 2005, the French Ministry of Culture awarded Smith the

title of Commandeur des Arts et des Lettres; she was inducted into the Rock and Roll Hall of Fame in 2007, and was awarded the key to New York City in 2021.

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決TIME 100 2021的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.