et的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到附近那裡買和營業時間的推薦產品

You’’re about to Make a Terrible Mistake: How Biases Distort Decision-Making and What You Can Do to Fight Them

為了解決et的問題，作者Sibony, Olivier 這樣論述：

Olivier Sibony is an Affiliate Professor of Strategy at HEC Paris and an Associate Fellow at Saïd Business School, Oxford University. Previously, he spent 25 years in the Paris and New York offices of McKinsey & Company, where he was a senior partner. Sibony’s research on improving the quality of st

rategic decision making has been featured in many publications, including Harvard Business Review and MIT Sloan Management Review. He is a graduate of HEC Paris and hold a PhD from Paris Sciences et Lettres University.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決et的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Ancient Sources, Modern Appropriations: The Selected Writings of Hans-Georg Gadamer: Volume III

為了解決et的問題，作者Gadamer, Hans-Georg 這樣論述：

Hans-Georg Gadamer was born on 11 February 1900 and died on 13 March 2002. He was the author, most notably, of Truth and Method, and, more recently, of The Beginning of Philosophy and The Beginning of Knowledge.Arun Iyer is an instructor in Philosophy at Seattle University, USA. He is the author of

Towards an Epistemology of Ruptures: The Case of Heidegger and Foucault (2014).Pol Vandevelde is Professor of Philosophy at Marquette University, USA. His previous publications include Être et Discours: La Question du Langage dans L’itinéraire de Heidegger (1927-1938) (1994) The Task of the Interpre

ter: Text, Meaning, and Negotiation (2005) and Heidegger and the Romantics: the Literary Invention of Meaning (2012).

戶外探索教育推動歷程之探究－以臺東縣均一實驗中學為例

為了解決et的問題，作者高睿哲 這樣論述：

　　本研究者從自身參與探索教育之經驗出發，以臺東縣均一實驗中學的戶外探索教育推動歷程進行個案研究。此研究以質性研究方法，透過觀察、訪談、及文件資料分析等方式蒐集研究相關資料，並將所得資料進行分析、歸納後，藉以探究個案學校在推動戶外探索教育發展之相關經驗。研究結論如下：一、臺東縣均一實驗中學推動戶外探索教育之發展歷程四個階段：社團活動期、師資召募發展期、課程定位調整期、課程轉型期。二、臺東縣均一實驗中學推動戶外探索教育之期待為：藉由帶領學生脫離舒適圈，在具有風險管控的戶外場域中，進行身體探索與心靈反思，培養對自我的肯定、與他人的合作、以及對土地關懷與人文素養。三、臺東縣均一實驗中學推動戶外探索

教育帶來之影響為：學校端：家長認同、校譽提升、利於招生。教職員端：擴充教學能量、培養運動習慣、增進校內同仁情誼、獲得教學成就感。學生端：脫離舒適圈、探索自我、提升學習意願、增進適應能力。家長端：增進親子互動、更願意支持學校。四、臺東縣均一實驗中學推動戶外探索教育面臨之問題與困境為：參與者狀態的不確定性、行政端與教學端溝通不良、課程比重與時間配當問題、期待更多的理解與支持。