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Japan’s Tin Drum

為了解決Project的問題，作者Pyzik, Agata 這樣論述：

Agata Pyzik is a Polish writer active in Great Britain since 2010. She’s the author of the critically acclaimed Poor but Sexy (2014). Pyzik publishes widely since 2004, covering mostly culture, music and politics. Among her main interests are the Cold War, post-war modernism, post-punk and Soviet hi

story. Currently she’s working on a project for Penguin, on the cultural aspects of global political change in the late 1980s and early 1990s.

Project進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Project的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Lego Mad Libs

為了解決Project的問題，作者Seim, Lindsay 這樣論述：

Lindsay Seim is an actor and writer based in Los Angeles. In addition to writing several Mad Libs titles (Penguin Random House), Lindsay’s essays and short stories have been featured in XO Jane, Betty Confidential, and the Plains Song Review. She is a Hearst Journalism Award recipient and wrote the

screenplay for the sci-fi feature film A Wakefield Project, in which she also co-starred.Lindsay grew up acting in plays written by her sister, Carrie Seim, and riding horses in the wide open spaces of Nebraska.

自動化安全檢核方法之研究

為了解決Project的問題，作者郭民瑜 這樣論述：

隨著科技的進步，金融業所提供的服務也越來越廣泛，系統的架構也從傳統的大型主機漸漸走向開放式的系統，虛擬化技術也漸漸的應用在金融服務業上，而系統越開放資訊安全也就更加的重要。所提供的服務越多也代表背後需要有更多的主機來支撐這些服務，面對越來越多的主機系統，如何有效的管理這些主機的安全設定也就成為課題之一。因此，使用自動化管理提升效率並且降低人為錯誤便成為系統管理的一種趨勢。本論文之研究使用Ansible管理工具建立自動化檢核架構，利用編寫好的Playbook針對目標主機進行系統安全的檢核，並將檢核結果輸出成報表。由於Ansible管理工具無須安裝代理程式的特性，可節省大量佈署代理程式的時間，大

幅降低人力成本。另外Ansible自動化檢核的速度也比傳統人工檢核所花費的時間快上不少，也節省時間成本。